Opening Conference - Program
DAY 1: MONDAY 6 MAY 2019
8:00 am – 8:30 am
Registration – coffee
8:30 am – 8:45 am
Welcoming Address
Martin Lohse (Scientific Director, MDC)
Axel Pries (Dean, Charité – Universitätsmedizin Berlin; – CEO (interim), Berlin Institute of Health BIH)
André le Bivic (Director of the Institute of Biological Sciences, CNRS)
Otmar Wiestler (President, Helmholtz Association)
8:45 am – 9:15 am
Introduction by Nikolaus Rajewsky and Geneviève Almouzni (LifeTime coordinators)
9:15 am – 11:40 am
Session 1: Single-cell multi-omics
Hosted by WP3 (leads: Giacomo Cavalli and Amos Tanay)
9:15 am – 9:35 am
Amos Tanay, The Weizmann Institute for Sciences, Rehovot, Israel
Introduction to WP3: Single-cell multi-omics
9:35 am – 9:55 am
Prisca Liberali, Friedrich-Miescher-Institute for Biomedical Research, Basel Switzerland
Single cells in space and time during development
9:55 am – 10:15 am
Marcelo Nollmann, Centre National de la Recherche Scientifique, Montpellier, France
Seeing is believing: new breakthroughs in imaging technologies
10:15 am – 10:40 am
Coffee time
10:40 am – 11:00 am
Alexander Van Oudenaarden, Hubrecht Institute, Utrecht, The Netherlands
Lineage reconstruction by single-cell sequencing
11:00 am – 11:20 am
Robert Balderas, BD Biosciences, USA
Co-creation of innovative tools for Single Cell Multi-omics
11:20 am – 11:30 am
Mats Nilsson, SciLifeLab, Solna, Sweden
Spatial cell-maps of molecularly defined cell types using targeted in situ sequencing
11:30 am – 11:40 am
Marlies Vanden Bempt, VIB, Belgium
Single cell profiling of different cancer types before and during immune
checkpoint therapy
11:40 am – 12:10 pm
Cross topics: Innovation & Training
Hosted by WP7 and WP10 (leads: Jan Ellenberg, Susan Gasser,
Joachim Schultze, Marek Figlerowicz and Dimitris Thanos)
12:10 pm – 13:30 pm
Lunch time / poster session
13:30 pm – 15:30 pm
Session 2: Data science, AI & Machine learning
Hosted by WP4 (leads: John Marioni, Marc Marti-Renom and Helen Parkinson)
13:30 pm – 13:50 pm
Helen Parkinson, EMBL-EBI, Wellcome Genome Campus, Hinxton
Introduction to WP4: Data science, AI & machine learning
13:50 pm – 14:10 pm
Fabian Theis, Institute of Computational Biology, Helmholtz Center Munich, Germany
Large-scale lineage and latent-space learning in single-cell genomics
14:10 pm – 14:30 pm
Jean-Philippe Vert, Google, France
Learning representations of single cell data
14:30 pm – 14:50 pm
Nir Friedman, HUJI – The Hebrew University of Jerusalem, Rehovot, Israel
From factoids to knowledge – how do we connect the dots?
14:50 pm – 15:10 pm
Anna Kreshuk, EMBL – The European Molecular Biology Laboratory,
Heidelberg, Germany
Image analysis with machine learning
15:10 pm – 15:20 pm
Matthias Becker, DZNE – German Center for Neurodegenerative Diseases,
Bonn, Germany
Memory-Driven Computing: A novel architecture for growing single-cell data sets
15:20 pm – 15:30 pm
Mario Nicodemi, University of Naples, Italy
Machine Learning Chromatin Architecture in Single Cells by Polymer Physics
15:30 pm – 16:00 pm
Coffee time
16:00 pm – 18:00 pm
Session 3: Experimental disease models
Hosted by WP5 (leads: Jürgen Knoblich, Jean-Christophe Marine and Giuseppe Testa)
16:00 pm – 16:20 pm
Giuseppe Testa, IEO – European Institute of Oncology & University of Milan, Milano, Italy
De humani corporis fabrica: the new landscape of experimental models for
charting disease dynamics at single cell resolution
16:20 pm – 16:40 pm
Jürgen Knoblich, IMBA – Institute of Molecular Biotechnology, Vienna, Austria
Modeling human development and disease in Cerebral organoids
16:40 pm – 17:00 pm
Cédric Blanpain, ULB – Université Libre de Bruxelles, Brussels, Belgium
Deciphering cellular heterogeneity and lineage segregation during embryonic
development, tissue homeostasis and tumorigenesis using single cell RNA sequencing
17:00 pm – 17:20 pm
Paul Vulto, Mimetas, Netherlands
Organ-on-a-Chip technology as a routine tool in drug discovery and development
17:20 pm – 17:40 pm
Barbara Treutlein, ETH Zurich, Switzerland
TBC
17:40 pm – 17:50 pm
Eleonora Leucci, Trace PDX platform-LKI, Leuven, Belgium
TRACE & the EurOPDX Research Infrastructure: providing cutting-edge
translational cancer research, expertise, & services.
17:50 pm – 18:00 pm
Sven Nelander, Uppsala University, Uppsala, Sweden
Therapeutic targets from big data: integrative discovery of treatments
for high-risk neuroblastoma
18:00 pm – 18:15 pm
Short break
18:15 pm – 18:30 pm
Sabine Oertelt-Prigione, Radboud University in Nijmegen, Netherlands
The impact of sex differences on biomedical research
18:30 pm – 19:00 pm
Keynote: Angelika Eggert, Charité, Berlin, Germany
Creating the basis for tomorrow’s cancer precision medicine
19:00 pm – 19:10 pm
Welcoming Address
Steffen Krach (Secretary of State, Berlin, Germany)
19:10 pm – 22:00 pm
Evening reception
DAY 2: TUESDAY 7 MAY 2019
9:00 am – 9:45 am
Keynote: Alfonso Valencia, BSC – Barcelona Supercomputing Center, Barcelona, Spain
From data to models: infrastructures and resources for the challenges of the future medicine
9:45 am – 10:15 am
Cross topics: ELSI & communication
Hosted by WP8 and WP9 (leads: Annelien Bredenoord, Maria-Elena Torres-Padilla, Leila Périé, Wolf Reik and Stephan Preibisch)
10:15 am – 10:45 am
Coffee time
10:45 am – 12:45 pm
Session 4: LifeTime Launchpad – disease focus
Hosted by WP6 (leads: Peter Lichter and Mihai Netea)
10:45 am – 11:15 am
Mihai Netea, Radboud University Medical Center, Nijmegen, the Netherlands
Jan van Lunzen, ViiV Healthcare, UK
A functional genomics approach to characterize inflammation in disease:
the case of HIV infection
11:15 am – 11:35 am
Bart De Strooper, KU Leuven, VIB, and UK-Dementia research Institute
Single-cell approaches and humanized Alzheimer Disease models:
opportunities for real progress
11:35 am – 11:55 am
Georg Schett, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany
Towards a molecular pathology of chronic inflammatory disease
11:55 am – 12:15 pm
Wilko Weichert, Institute of Pathology, Technical University Munich (TUM), Germany
Cancer. On how to attack the emperor of all maladies
12:15 am – 12:25 pm
Céline Vallot, Institut Curie, Paris, France
Single-cell chromatin profiling reveals heterogeneity of chromatin
landscapes in breast cancer
12:25 am – 12:35 pm
Kathrin Kattler, Saarland University, Saarbrücken, Germany
Spatial transcriptomic and epigenomic maps of human liver: blueprints for
projection of single cell data into hepatic pseudospace
12:35 am – 12:45 pm
Claudia Ctortecka, IMP – Research Institute of Molecular Pathology, Vienna, Austria
In depth profiling of cardiac spheres to decipher cardiac progenitor functionality
12:45 pm – 14:15 pm
Lunch time / poster session
14:15 pm – 16:15 pm
Parallel breakout sessions, including coffee
Sessions on WP3, 4, 5 and 6 in different rooms
From the state of the art to LifeTime objectives
16:15 pm – 17:15 pm
Wrap up and closing